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Article

Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.

Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2000

O'Brien S P, Seipel K, Medley Q G, Bronson R, Segal R, Streuli M

Abstract excerpt

Dbl-homology guanine nucleotide exchange factors (DH-GEFs) regulate actin cytoskeletal reorganization, cell adhesion, and gene transcription via activation of Rho GTPases. However, little is known about the physiological role of mammalian DH-GEFs during development. The DH-GEF family member Trio is of particular interest because it is a multifunctional protein possessing two GEF domains, as well as a protein...

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Identifiers

PMID: 11050238
DOI: 10.1073/pnas.97.22.12074
PMCID: PMC17296

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.PMID 11050238Read ↗

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Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding.Semantic proximity Read ↗

The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth.Semantic proximity Read ↗

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Mutations specific to the Rac-GEF domain of <i>TRIO</i> cause intellectual disability and microcephalySemantic proximity Read ↗

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