Article
Effects of mutations in pleckstrin homology domain on beta-adrenergic receptor kinase activity in intact cells.
Biochemical and biophysical research communications - 27 Nov 1998
Touhara K
Abstract excerpt
beta-Adrenergic receptor kinase (betaARK) plays a pivotal role in phosphorylating and desensitizing G protein coupled receptors by virtue of pleckstrin homology (PH) domain-mediated membrane translocation. betaARK is localized to the specific membrane compartment by betagamma subunits of G protei...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Blood Proteins
- COS Cells
- Cell Line
- Cyclic AMP-Dependent Protein Kinases
- GTP-Binding Proteins
- Ligands
- Molecular Sequence Data
- Mutation
- Phosphatidylinositol 4,5-Diphosphate
- Phosphoproteins
- Phosphorylation
- Rhodopsin
- Sequence Homology, Amino Acid
- Spodoptera
- beta-Adrenergic Receptor Kinases