Roles of the phosphorylation sites of distinct α1A-adrenergic receptor domains.

Abstract excerpt

Phosphorylation participates in the signaling, localization, and trafficking of G protein-coupled receptors. In this study, the amino acids known to be phosphorylated in α1A-adrenergic receptors were substituted with nonphosphorylatable residues in intracellular loop 3 (IL3) mutant, the carboxyl terminus (CTerm) mutant, and both structural regions (IL3-CTerm mutant). Their functions were compared with those of...

Topics

• Phosphorylation
• Receptors, Adrenergic, alpha-1
• Animals
• Humans
• Protein Domains
• Protein Kinase C