Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

doi:10.1074/jbc.273.45.29600

Article

Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

The Journal of biological chemistry - 6 Nov 1998

Sable C L, Filippa N, Filloux C, Hemmings B A, Van Obberghen E

Abstract excerpt

Involvement of the pleckstrin homology (PH) domain in the insulin-stimulated activation of protein kinase B (PKB) was investigated in human embryonic kidney 293 cells. Different PKB constructs that contain mutations or deletions in the PH domain were transfected into cells, and the results on the basal and insulin-induced kinase activities were analyzed. Deletion of the entire PH domain (DeltaPH-PKB) did not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

Abstract excerpt

Topics

Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

Abstract excerpt

Topics

Related research