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Article

Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

The Journal of biological chemistry - 6 Nov 1998

Sable C L, Filippa N, Filloux C, Hemmings B A, Van Obberghen E

Abstract excerpt

Involvement of the pleckstrin homology (PH) domain in the insulin-stimulated activation of protein kinase B (PKB) was investigated in human embryonic kidney 293 cells. Different PKB constructs that contain mutations or deletions in the PH domain were transfected into cells, and the results on the...

Topics

Blood Proteins
Cell Line
Enzyme Activation
Humans
Insulin
Mutation
Phosphoproteins
Phosphorylation
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-akt

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Identifiers

PMID: 9792669
DOI: 10.1074/jbc.273.45.29600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9792669-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.PMID 9792669Read ↗

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Effects of mutations in pleckstrin homology domain on beta-adrenergic receptor kinase activity in intact cells.Semantic proximity Read ↗

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Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.Semantic proximity Read ↗

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