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Article

Regulatory properties of alpha(1B)-adrenergic receptors defective in coupling to phosphoinositide hydrolysis.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2002

Wang Jiefa, Wang Lei, Anderson Jodi L, Schulte Nancy A, Toews Myron L

Abstract excerpt

Previous studies have suggested that G protein coupling, phospholipase C activation, phosphoinositide hydrolysis, and protein kinase C activation may be required for alpha(1B)-adrenergic receptor regulation, particularly for their endocytosis into intracellular vesicles. Accordingly, the internalization and down-regulation properties of mutated receptors with defects in G protein coupling and second messenger...

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Source

Identifiers

PMID: 11752108
DOI: 10.1124/jpet.300.1.134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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