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Article

Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels.

The Journal of biological chemistry - 1 Mar 2002

Mirshahi Tooraj, Robillard Liliane, Zhang Hailin, Hébert Terence E, Logothetis Diomedes E

Abstract excerpt

Gbetagamma subunits interact directly and activate G protein-gated Inwardly Rectifying K(+) (GIRK) channels. Little is known about the identity of functionally important interactions between Gbetagamma and GIRK channels. We tested the effects of all mammalian Gbeta subunits on channel activity and showed that whereas Gbeta1-4 subunits activate heteromeric GIRK channels independently of receptor activation, Gbeta5...

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Identifiers

PMID: 11707461
DOI: 10.1074/jbc.M109999200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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