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Article

Structural determinants for phosphatidic acid regulation of phospholipase C-beta1.

The Journal of biological chemistry - 3 Nov 2006

Ross Elliott M, Mateu Dania, Gomes Aldrin V, Arana Carlos, Tran Thanh, Litosch Irene

Abstract excerpt

Signaling from G protein-coupled receptors to phospholipase C-beta (PLC-beta) is regulated by coordinate interactions among multiple intracellular signaling molecules. Phosphatidic acid (PA), a signaling phospholipid, binds to and stimulates PLC-beta(1) through a mechanism that requires the PLC-beta(1) C-terminal domain. PA also modulates Galpha(q) stimulation of PLC-beta(1). These data suggest that PA may have a...

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PMID: 16950781
DOI: 10.1074/jbc.M606487200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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