Article
Molecular basis for interactions of G protein betagamma subunits with effectors.
Science (New York, N.Y.) - 22 May 1998
Ford C E, Skiba N P, Bae H, Daaka Y, Reuveny E, Shekter L R, Rosal R, Weng G, Yang C S, Iyengar R, Miller R J, Jan L Y, Lefkowitz R J, Hamm H E
Abstract excerpt
Both the alpha and betagamma subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins) communicate signals from receptors to effectors. Gbetagamma subunits can regulate a diverse array of effectors, including ion channels and enzymes. Galpha subunits bound to guanine diphosphate...
Topics
- Adenosine Diphosphate Ribose
- Adenylyl Cyclases
- Binding Sites
- Calcium Channels
- Cell Line
- Cyclic AMP-Dependent Protein Kinases
- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- GTP-Binding Proteins
- Guanosine Diphosphate
- Heterotrimeric GTP-Binding Proteins