Article
Molecular basis for interactions of G protein betagamma subunits with effectors.
Science (New York, N.Y.) - 22 May 1998
Ford C E, Skiba N P, Bae H, Daaka Y, Reuveny E, Shekter L R, Rosal R, Weng G, Yang C S, Iyengar R, Miller R J, Jan L Y, Lefkowitz R J, Hamm H E
Abstract excerpt
Both the alpha and betagamma subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins) communicate signals from receptors to effectors. Gbetagamma subunits can regulate a diverse array of effectors, including ion channels and enzymes. Galpha subunits bound to guanine diphosphate (Galpha-GDP) inhibit signal transduction through Gbetagamma subunits, suggesting a common interface on Gbetagamma...
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