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Article

Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits.

The Journal of physiology - 1 Jun 2007

Cockerill S L, Tobin A B, Torrecilla I, Willars G B, Standen N B, Mitcheson J S

Abstract excerpt

The human ether-a-go-go related gene (hERG) potassium channel is expressed in a variety of tissues including the heart, neurons and some cancer cells. hERG channels are modulated by several intracellular signalling pathways and these provide important mechanisms for regulating cellular excitability. In this study, we investigated muscarinic modulation of hERG currents and direct phosphorylation of channel...

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Identifiers

PMID: 17363390
DOI: 10.1113/jphysiol.2006.123414
PMCID: PMC2075202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits.PMID 17363390Read ↗

Molecular analysis of PIP2 regulation of HERG and IKr.Semantic proximity Read ↗

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Potassium channel phosphorylation in excitable cells: providing dynamic functional variability to a diverse family of ion channels.Semantic proximity Read ↗

Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperatureSemantic proximity Read ↗

AMP-activated protein kinase regulates hERG potassium channel.Semantic proximity Read ↗

Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G.Semantic proximity Read ↗

Protein kinase Calpha modulates depolarizaton-evoked changes of intracellular Ca2+ concentration in a rat pheochromocytoma cell line.Semantic proximity Read ↗

Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems.Semantic proximity Read ↗

Functional characterization of the C-terminus of the human ether-à-go-go-related gene K(+) channel (HERG).Semantic proximity Read ↗

Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source.Semantic proximity Read ↗

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