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Article

Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation.

The Journal of biological chemistry - 16 May 2003

Storz Peter, Döppler Heike, Johannes Franz-Josef, Toker Alex

Abstract excerpt

Protein kinase D (PKD) is a member of the AGC family of Ser/Thr kinases and is distantly related to protein kinase C (PKC). Formerly known as PKCmu, PKD contains protein domains not found in conventional PKC isoforms. A functional pleckstrin homology (PH) domain is critical for the regulation of PKD activity. Here we report that PKD is tyrosine-phosphorylated within the PH domain, leading to activation. This...

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Identifiers

PMID: 12637538
DOI: 10.1074/jbc.M213224200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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