Article
The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone.
Endocrinology - 1 Dec 1998
Lanske B, Divieti P, Kovacs C S, Pirro A, Landis W J, Krane S M, Bringhurst F R, Kronenberg H M
Abstract excerpt
PTH and PTH-related peptide (PTHrP) have been shown to bind to and activate the same PTH/PTHrP receptor. Recent studies have demonstrated, however, the presence of additional receptors specific for each ligand. We used the PTHrP and PTH/PTHrP receptor gene knock-out models to investigate whether...
Topics
- Animals
- Bone Density
- Bone Resorption
- Bone and Bones
- Cell Differentiation
- Chondrocytes
- Growth Plate
- Ligands
- Mice
- Mice, Knockout
- Microscopy, Electron
- Mutation
- Osteoblasts
- Parathyroid Hormone
- Parathyroid Hormone-Related Protein
- Phenotype
- Proteins
- Receptor, Parathyroid Hormone, Type 1