Article
The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone.
Endocrinology - 1 Dec 1998
Lanske B, Divieti P, Kovacs C S, Pirro A, Landis W J, Krane S M, Bringhurst F R, Kronenberg H M
Abstract excerpt
PTH and PTH-related peptide (PTHrP) have been shown to bind to and activate the same PTH/PTHrP receptor. Recent studies have demonstrated, however, the presence of additional receptors specific for each ligand. We used the PTHrP and PTH/PTHrP receptor gene knock-out models to investigate whether this receptor mediates the actions of both ligands in bone. The similar phenotype of the PTHrP (-/-) and PTH/PTHrP...
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