Article
Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997
Schipani E, Lanske B, Hunzelman J, Luz A, Kovacs C S, Lee K, Pirro A, Kronenberg H M, Jüppner H
Abstract excerpt
Mice in which the genes encoding the parathyroid hormone (PTH)-related peptide (PTHrP) or the PTH/PTHrP receptor have been ablated by homologous recombination show skeletal dysplasia due to accelerated endochondral bone formation, and die at birth or in utero, respectively. Skeletal abnormalities due to decelerated chondrocyte maturation are observed in transgenic mice where PTHrP expression is targeted to the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.