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Article

Role of PTH1R internalization in osteoblasts and bone mass using a phosphorylation-deficient knock-in mouse model.

The Journal of endocrinology - 1 Dec 2010

Datta Nabanita S, Samra Tareq A, Mahalingam Chandrika D, Datta Tanuka, Abou-Samra Abdul B

Abstract excerpt

Phosphorylation, internalization, and desensitization of G protein-coupled receptors, such as the parathyroid hormone (PTH) and PTH-related peptide (PTHrP) receptor (PTH1R), are well characterized and known to regulate the cellular responsiveness in vitro. However, the role of PTH1R receptor phosphorylation in bone formation and osteoblast functions has not yet been elucidated. In previous studies, we...

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Source

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Identifiers

PMID: 20929987
DOI: 10.1677/JOE-10-0227
PMCID: PMC3771320

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of PTH1R internalization in osteoblasts and bone mass using a phosphorylation-deficient knock-in mouse model.PMID 20929987Read ↗

Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor.Semantic proximity Read ↗

Eliminating phosphorylation sites of the parathyroid hormone receptor type 1 differentially affects stimulation of phospholipase C and receptor internalization.Semantic proximity Read ↗

Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.Semantic proximity Read ↗

The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone.Semantic proximity Read ↗

Disruption of β-catenin binding to parathyroid hormone (PTH) receptor inhibits PTH-stimulated ERK1/2 activation.Semantic proximity Read ↗

Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism.Semantic proximity Read ↗

Phosphorylation of the receptor for PTH and PTHrP is required for internalization and regulates receptor signaling.Semantic proximity Read ↗

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.Semantic proximity Read ↗

TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling.Semantic proximity Read ↗

Inducible activation of PKA in osteoblasts causes a profound high bone turnover phenotype similar to human diseasesSemantic proximity Read ↗

The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.Semantic proximity Read ↗

Conditionally immortalized murine osteoblasts lacking the type 1 PTH/PTHrP receptor.Semantic proximity Read ↗

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