Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.

The Journal of clinical investigation - 1 Aug 1999

Lanske B, Amling M, Neff L, Guiducci J, Baron R, Kronenberg H M

Abstract excerpt

Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) bind to and activate the same PTH/PTHrP receptor. Deletion of either the PTHrP gene or the PTH/PTHrP receptor gene leads to acceleration of differentiation of growth plate chondrocytes. To explore further the functional relationships of PTHrP and the PTH/PTHrP receptor, bones of knockout mice were analyzed early in development, and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Development

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Osteoblasts

Share to Parathyroid Hormone-Related Protein

Share to Pregnancy

Share to Proteins

Share to Receptor, Parathyroid Hormone, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 10449432
DOI: 10.1172/JCI6629
PMCID: PMC408525

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.PMID 10449432Read ↗

The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone.Semantic proximity Read ↗

Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice.Semantic proximity Read ↗

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.Semantic proximity Read ↗

Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.Semantic proximity Read ↗

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.Semantic proximity Read ↗

The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.Semantic proximity Read ↗

Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene.Semantic proximity Read ↗

Parathyroid hormone-related protein is required for tooth eruption.Semantic proximity Read ↗

Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.Semantic proximity Read ↗

Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.Semantic proximity Read ↗

Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development.Semantic proximity Read ↗

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.