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Article

The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.

Developmental cell - 1 Aug 2002

Guo Jun, Chung Ung-Il, Kondo Hisatomo, Bringhurst F Richard, Kronenberg Henry M

Abstract excerpt

One G protein-coupled receptor (GPCR) can activate more than one G protein, but the physiologic importance of such activation has not been demonstrated in vivo. We have generated mice expressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase normally but not phospholipase C (PLC). DSEL mutant mice exhibit abnormalities in embryonic endochondral bone development,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12194850
DOI: 10.1016/s1534-5807(02)00218-6

Genes

PTH
DSEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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