Article
Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.
Development (Cambridge, England) - 1 Apr 1998
Wysolmerski J J, Philbrick W M, Dunbar M E, Lanske B, Kronenberg H, Broadus A E
Abstract excerpt
Parathyroid hormone-related protein (PTHrP) was originally discovered as a tumor product that causes humoral hypercalcemia of malignancy. PTHrP is now known to be widely expressed in normal tissues and growing evidence suggests that it is an important developmental regulatory molecule. We had pre...
Topics
- Animals
- Cells, Cultured
- Gene Deletion
- Gene Expression Regulation, Developmental
- Gene Transfer Techniques
- Immunohistochemistry
- In Situ Hybridization
- Mammary Glands, Animal
- Mice
- Mice, Knockout
- Morphogenesis
- Parathyroid Hormone-Related Protein
- Phenotype
- Proteins