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Article

Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.

Development (Cambridge, England) - 1 Apr 1998

Wysolmerski J J, Philbrick W M, Dunbar M E, Lanske B, Kronenberg H, Broadus A E

Abstract excerpt

Parathyroid hormone-related protein (PTHrP) was originally discovered as a tumor product that causes humoral hypercalcemia of malignancy. PTHrP is now known to be widely expressed in normal tissues and growing evidence suggests that it is an important developmental regulatory molecule. We had previously reported that overexpression of PTHrP in the mammary glands of transgenic mice impaired branching morphogenesis...

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Source

Identifiers

PMID: 9477327
DOI: 10.1242/dev.125.7.1285

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.PMID 9477327Read ↗

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Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes.Semantic proximity Read ↗

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.Semantic proximity Read ↗

Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction<sup>1</sup>Semantic proximity Read ↗

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