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Article

Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene.

Endocrinology - 1 Dec 2001

Soegiarto D W, Kiachopoulos S, Schipani E, Jüppner H, Erben R G, Lanske B

Abstract excerpt

The homozygous ablation of the gene encoding the PTH/PTHrP receptor (PPR(-/-)) leads to early lethality and limited developmental defects, including an acceleration of chondrocyte differentiation. In contrast to the findings in homozygous PTHrP-ablated (PTHrP(-/-)) animals, these PPR(-/-) mice show an increase in cortical bone, a decrease in trabecular bone, and a defect in bone mineralization. Opposite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11713230
DOI: 10.1210/endo.142.12.8553

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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