Article
Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.
The Journal of clinical investigation - 1 Feb 2001
Calvi L M, Sims N A, Hunzelman J L, Knight M C, Giovannetti A, Saxton J M, Kronenberg H M, Baron R, Schipani E
Abstract excerpt
Parathyroid hormone (PTH), an important regulator of calcium homeostasis, targets most of its complex actions in bone to cells of the osteoblast lineage. Furthermore, PTH is known to stimulate osteoclastogenesis indirectly through activation of osteoblastic cells. To assess the role of the PTH/PTH-related protein receptor (PPR) in mediating the diverse actions of PTH on bone in vivo, we generated mice that...
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