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Article

Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology.

American journal of physiology. Renal physiology - 1 Nov 2009

Meir Tomer, Levi Ronen, Lieben Liesbet, Libutti Steven, Carmeliet Geert, Bouillon Roger, Silver Justin, Naveh-Many Tally

Abstract excerpt

1,25(OH)2D3 decreases parathyroid hormone (PTH) gene transcription through the vitamin D receptor (VDR). Total body VDR(-/-) mice have high PTH levels, hypocalcemia, hypophosphatemia, and bone malformations. To investigate PTH regulation by the VDR specifically in the parathyroid, we generated parathyroid-specific VDR knockout mice (PT-VDR(-/-)). In both strains, there was a decrease in parathyroid calcium...

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Source

Identifiers

PMID: 19692484
DOI: 10.1152/ajprenal.00360.2009

Genes

VDR
PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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