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Article

Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice.

Vitamins and hormones - 1 Jan 1996

Karaplis A C, Kronenberg H M

Abstract excerpt

A null mutation in the PTHrP gene produces profound abnormalities in endochondral bone formation in vivo. The role of PTHrP as a modulator of the chondrocytic proliferation and differentiation program is evident in the alterations that occur in its absence in the temporal and spatial sequence of...

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Source

Identifiers

PMID: 8909161
DOI: 10.1016/s0083-6729(08)60411-2

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8909161-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice.PMID 8909161Read ↗

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.Semantic proximity Read ↗

The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone.Semantic proximity Read ↗

The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.Semantic proximity Read ↗

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.Semantic proximity Read ↗

Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.Semantic proximity Read ↗

Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse modelSemantic proximity Read ↗

Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene.Semantic proximity Read ↗

Parathyroid hormone-related protein is required for tooth eruption.Semantic proximity Read ↗

Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.Semantic proximity Read ↗

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.Semantic proximity Read ↗

The PTH/PTHrP receptor in Jansen's metaphyseal chondrodysplasia.Semantic proximity Read ↗

Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles.Semantic proximity Read ↗

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