Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.

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Article

Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.

Cancer research - 15 Nov 1998

Kodama S, Kashino G, Suzuki K, Takatsuji T, Okumura Y, Oshimura M, Watanabe M, Barrett J C

Abstract excerpt

The Werner syndrome (WS) gene (WRN) was isolated by positional cloning, based on mapping to chromosome 8p12, and the WRN protein was recently shown to encode an active helicase. To examine functional complementation of WS phenotypes by expression of the WRN gene, we introduced a normal human chromosome 8 into a SV40-transformed WS fibroblastoid cell line (WS780) by microcell fusion and studied several cellular...

Read the complete abstract on PubMed

Topics

4-Nitroquinoline-1-oxide
Animals
Carcinogens
Cell Fusion
Cell Line, Transformed
Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Chromosomes, Human, Pair 8

Chromosomes, Human, Pair 9

DNA Helicases

Exodeoxyribonucleases

Gene Deletion

Genetic Complementation Test

Humans

Hypoxanthine Phosphoribosyltransferase

Mice

Microsatellite Repeats

Mutation

Phenotype

Source

Open in PubMed

Identifiers

PMID: 9823331

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.PMID 9823331Read ↗

Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene.Semantic proximity Read ↗

Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines.Semantic proximity Read ↗

Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.Semantic proximity Read ↗

Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.Semantic proximity Read ↗

Werner syndrome cells escape hydrogen peroxide‐induced cell proliferation arrestSemantic proximity Read ↗

Functional role of the Werner syndrome RecQ helicase in human fibroblasts.Semantic proximity Read ↗

Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.Semantic proximity Read ↗

Exogenous expression of exonuclease domain-deleted WRN interferes with the repair of radiation-induced DNA damages.Semantic proximity Read ↗

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WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.Semantic proximity Read ↗

Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.Semantic proximity Read ↗

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