Article
Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.
Cancer research - 15 Nov 1998
Kodama S, Kashino G, Suzuki K, Takatsuji T, Okumura Y, Oshimura M, Watanabe M, Barrett J C
Abstract excerpt
The Werner syndrome (WS) gene (WRN) was isolated by positional cloning, based on mapping to chromosome 8p12, and the WRN protein was recently shown to encode an active helicase. To examine functional complementation of WS phenotypes by expression of the WRN gene, we introduced a normal human chro...
Topics
- 4-Nitroquinoline-1-oxide
- Animals
- Carcinogens
- Cell Fusion
- Cell Line, Transformed
- Cell Transformation, Viral
- Chromosomes, Human, Pair 8
- Chromosomes, Human, Pair 9
- DNA Helicases
- Exodeoxyribonucleases
- Gene Deletion
- Genetic Complementation Test
- Humans
- Hypoxanthine Phosphoribosyltransferase