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Article

Exogenous expression of exonuclease domain-deleted WRN interferes with the repair of radiation-induced DNA damages.

Journal of radiation research - 1 Dec 2005

Kashino Genro, Kodama Seiji, Suzuki Keiji, Matsumoto Takehisa, Watanabe Masami

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive disease characterized by multiple progeroid features. The gene responsible for WS, WRN, is a member of the human RecQ helicase family. WRN is unique among this family, associated with an exonuclease activity. In the present study, we established the human 293-derived cell lines, which expressed exogenously truncated WRN protein, lacking the N-terminal exonuclease...

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Source

Identifiers

PMID: 16394631
DOI: 10.1269/jrr.46.407

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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