Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines.

Human genetics - 1 Jan 2000

Prince P R, Ogburn C E, Moser M J, Emond M J, Martin G M, Monnat R J

Abstract excerpt

We have shown that Werner syndrome (WRN) fibroblast cell lines are unusually sensitive to the DNA-damaging agent 4-nitroquinoline 1-oxide (4NQO), though not to gamma radiation or to hydrogen peroxide. The fusion of 4NQO-sensitive WRN and 4NQO-resistant control fibroblast cell lines generated proliferating WRN x control cell hybrids that expressed WRN protein and were 4NQO-resistant. These results establish the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 4-Nitroquinoline-1-oxide
Share to Cell Fusion
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Survival

Share to Dose-Response Relationship, Radiation

Share to Drug Resistance

Share to Mutagens

Share to Werner Syndrome

Source

Identifiers

PMID: 10480367
DOI: 10.1007/s004399900078

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines.PMID 10480367Read ↗

Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.Semantic proximity Read ↗

WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.Semantic proximity Read ↗

Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.Semantic proximity Read ↗

Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene.Semantic proximity Read ↗

Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.Semantic proximity Read ↗

Werner syndrome cells escape hydrogen peroxide‐induced cell proliferation arrestSemantic proximity Read ↗

Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.Semantic proximity Read ↗

Exogenous expression of exonuclease domain-deleted WRN interferes with the repair of radiation-induced DNA damages.Semantic proximity Read ↗

Loss of Werner syndrome protein function promotes aberrant mitotic recombination.Semantic proximity Read ↗

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants.Semantic proximity Read ↗

Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stressSemantic proximity Read ↗

The repair of large DNA adducts in mammalian cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.