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Article

WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.

Cancer research - 1 May 2000

Hisama F M, Chen Y H, Meyn M S, Oshima J, Weissman S M

Abstract excerpt

WRN encodes a RecQ helicase, which is mutated in Werner syndrome. Werner syndrome is a genetic condition of young adults characterized by premature aging, limited replicative capacity of cells in vitro, and increased cancer risk. Telomerase is a reverse transcriptase that extends the G-rich strand of telomeric DNA. Primary cells in vitro typically lack telomerase activity and undergo senescence, whereas...

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Source

Identifiers

PMID: 10811112

Genes

WRN
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.PMID 10811112Read ↗

Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines.Semantic proximity Read ↗

Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.Semantic proximity Read ↗

Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.Semantic proximity Read ↗

Functional role of the Werner syndrome RecQ helicase in human fibroblasts.Semantic proximity Read ↗

Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene.Semantic proximity Read ↗

Werner Protein Protects Nonproliferating Cells from Oxidative DNA DamageSemantic proximity Read ↗

Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.Semantic proximity Read ↗

Mutations in the WRN gene in mice accelerate mortality in a p53-null background.Semantic proximity Read ↗

Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.Semantic proximity Read ↗

Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.Semantic proximity Read ↗

Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents.Semantic proximity Read ↗

Werner syndrome cells escape hydrogen peroxide‐induced cell proliferation arrestSemantic proximity Read ↗

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