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Article

Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene.

Journal of radiation research - 1 May 2009

Ariyoshi Kentaro, Suzuki Keiji, Goto Makoto, Oshimura Mitsuo, Ishizaki Kanji, Watanabe Masami, Kodama Seiji

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging and caused by mutations of the WRN gene mapped at 8p12. To examine functional complementation of WS phenotypes, we introduced a normal human chromosome 8 into a strain of WS fibroblasts (WS3RGB) immortalized by expressing a human telomerase reverse transcriptase subunit (hTERT) gene. Here, we demonstrate that the abnormal WS...

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Source

Identifiers

PMID: 19398855
DOI: 10.1269/jrr.08111

Genes

WRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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