Article
Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2002
Poot Martin, Gollahon Katherine A, Emond Mary J, Silber John R, Rabinovitch Peter S
Abstract excerpt
The clinical phenotype of Werner Syndrome (WRN) includes features reminiscent of accelerated aging and an increased incidence of sarcomas and other tumors of mesenchymal origin. This syndrome results from mutations in the WRN DNA helicase/exonuclease gene. We found that WRN deficient primary fibroblasts, as well as lymphoblastoid cell lines (LCLs), show reduced proliferative survival in response to...
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