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Article

Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.

Cancer science - 1 May 2008

Futami Kazunobu, Ishikawa Yuichi, Goto Makoto, Furuichi Yasuhiro, Sugimoto Masanobu

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive genetic disorder causing premature aging, and WRN has been identified as the causative gene of WS. The product of the WRN gene (WRN) acts as a DNA helicase with exonuclease activity, and data have accumulated showing that the WRN gene strongly participates in carcinogenesis: (1) the normal WRN gene likely participates in the immortalization of B-lymphoblastoid cell...

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Source

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Identifiers

PMID: 18312465
DOI: 10.1111/j.1349-7006.2008.00778.x
PMCID: PMC11158842

Genes

WRN

Provenance

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