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Article

Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.

Genetics - 1 Jan 2000

Wang L, Ogburn C E, Ware C B, Ladiges W C, Youssoufian H, Martin G M, Oshima J

Abstract excerpt

Mutations at the Werner helicase locus (WRN) are responsible for the Werner syndrome (WS). WS patients prematurely develop an aged appearance and various age-related disorders. We have generated transgenic mice expressing human WRN with a putative dominant-negative mutation (K577M-WRN). Primary tail fibroblast cultures from K577M-WRN mice showed three characteristics of WS cells: hypersensitivity to...

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Source

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Identifiers

PMID: 10628995
DOI: 10.1093/genetics/154.1.357
PMCID: PMC1460888

Genes

WRN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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