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Article

Reduction of Werner Syndrome Protein Enhances G:C → A:T Transition by O6-Methylguanine in Human Cells.

Chemical research in toxicology - 21 May 2018

Suzuki Tetsuya, Kuramoto Yoshie, Kamiya Hiroyuki

Abstract excerpt

O6-Methylguanine ( O6-MeG) is a damaged base produced by methylating reagents. The Werner syndrome protein (WRN) is a cancer-related human DNA helicase. The effects of WRN reduction on O6-MeG-caused mutagenesis were assessed by an siRNA-mediated knockdown in human U2OS cells, using a shuttle plasmid with a single O6-MeG base in the supF gene. The plasmid DNA was replicated in the cells, isolated, and...

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PMID: 29616805
DOI: 10.1021/acs.chemrestox.8b00009

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WRN

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