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Article

Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.

DNA repair - 2 Jan 2010

Dhillon Kiranjit K, Sidorova Julia M, Albertson Tina M, Anderson Judith B, Ladiges Warren C, Rabinovitch Peter S, Preston Bradley D, Monnat Raymond J

Abstract excerpt

Werner syndrome (WS) is a human autosomal recessive genetic instability and cancer predisposition syndrome with features of premature aging. Several genetically determined mouse models of WS have been generated, however, none develops features of premature aging or an elevated risk of neoplasia unless additional genetic perturbations are introduced. In order to determine whether differences in cellular phenotype...

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Source

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Identifiers

PMID: 19896421
DOI: 10.1016/j.dnarep.2009.09.013
PMCID: PMC2818259

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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