Article
Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.
The Journal of biological chemistry - 25 Apr 1992
Spivak-Kroizman T, Rotin D, Pinchasi D, Ullrich A, Schlessinger J, Lax I
Abstract excerpt
Ligand-induced dimerization of growth factor receptors is crucial for stimulation of their intrinsic protein tyrosine kinase activity promoting receptor autophosphorylation by an intermolecular mechanism. Moreover, the suppressive and negative dominant action of defective epidermal growth factor...
Topics
- 3T3 Cells
- Animals
- Cross-Linking Reagents
- Electrophoresis, Polyacrylamide Gel
- ErbB Receptors
- Humans
- Mice
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Receptor, ErbB-2