Article
Epidermal growth factor receptor (EGFR) signaling in cancer.
Gene - 17 Jan 2006
Normanno Nicola, De Luca Antonella, Bianco Caterina, Strizzi Luigi, Mancino Mario, Maiello Monica R, Carotenuto Adele, De Feo Gianfranco, Caponigro Francesco, Salomon David S
Abstract excerpt
The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins. Evidence suggests that the EGFR is involved in the pathogenesis and progression of different carcinoma types. The EGFR and EGF-like peptides are often over-expressed in human carcinomas,...
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