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Article

Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy.

FEBS letters - 18 Jun 2010

Pines Gur, Köstler Wolfgang J, Yarden Yosef

Abstract excerpt

The EGF-receptor is frequently mutated in a large variety of tumors. Here we review the most frequent mutations and conclude that they commonly enhance the intrinsic tyrosine kinase activity, or they represent loss-of-function of suppressive regulatory domains. Interestingly, the constitutive activity of mutant receptors translates to downstream pathways, which are subtly different from those stimulated by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20388509
DOI: 10.1016/j.febslet.2010.04.019
PMCID: PMC2892754

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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