Article
A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 1994
Moriai T, Kobrin M S, Hope C, Speck L, Korc M
Abstract excerpt
Epidermal growth factor (EGF) and type alpha transforming growth factor (TGF-alpha) bind to a specific region in subdomain III of the extracellular portion of the EGF receptor (EGFR). Binding leads to receptor dimerization, auto-and transphosphorylation on intracellular tyrosine residues, and act...
Topics
- Animals
- Arginine
- Binding Sites
- Blotting, Northern
- CHO Cells
- Cell Division
- Cloning, Molecular
- Codon
- Cricetinae
- DNA
- Epidermal Growth Factor
- ErbB Receptors
- Gene Expression
- Genes, fos
- Genes, jun
- Genes, myc
- Genetic Variation
- Humans