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Article

A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 1994

Moriai T, Kobrin M S, Hope C, Speck L, Korc M

Abstract excerpt

Epidermal growth factor (EGF) and type alpha transforming growth factor (TGF-alpha) bind to a specific region in subdomain III of the extracellular portion of the EGF receptor (EGFR). Binding leads to receptor dimerization, auto-and transphosphorylation on intracellular tyrosine residues, and activation of signal transduction pathways. We compared the binding and biological actions of EGF and TGF-alpha in Chinese...

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Identifiers

PMID: 7937865
DOI: 10.1073/pnas.91.21.10217
PMCID: PMC44989

Genes

EGF
EGFR
FOS
JUN
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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