Article
Epidermal Growth Factor Receptor Signaling to the Mitogen Activated Protein Kinase Pathway Bypasses Ras in Pancreatic Cancer Cells.
Pancreas - 1 Feb 2016
Lee Sangjun, Heinrich Eileen L, Lu Jianming, Lee Wendy, Choi Audrey H, Luu Carrie, Chung Vincent, Fakih Marwan, Kim Joseph
Abstract excerpt
OBJECTIVE: Epidermal growth factor (EGF) receptor (EGFR/HER1) is overexpressed in human pancreatic cancers. However, anti-EGFR therapy does not exhibit significant therapeutic activity with oncogenic K-ras mutation. We sought to assess the signaling relationship between EGFR and mutant K-ras, whi...
Topics
- Cell Line, Tumor
- Epidermal Growth Factor
- ErbB Receptors
- Extracellular Signal-Regulated MAP Kinases
- Humans
- Immunoblotting
- MAP Kinase Signaling System
- Mutation
- Pancreatic Neoplasms
- Phosphorylation
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins p21(ras)
- RNA Interference