Article
The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.
Molecular and cellular biology - 1 Jun 1991
Segatto O, Lonardo F, Wexler D, Fazioli F, Pierce J H, Bottaro D P, White M F, Di Fiore P P
Abstract excerpt
The epidermal growth factor receptor (EGFR) and gp185erbB-2 are closely related tyrosine kinases. Despite extensive sequence and structural homology, these two receptors display quantitative and qualitative differences in their ability to couple with mitogenic signalling pathways. By using chimeric molecules between EGFR and erbB-2, we found that the determinants responsible for the specificity of mitogenic...
Topics
- Amino Acid Sequence
- Animals
- Cell Division
- Cell Line
- Cell Membrane
- ErbB Receptors
- Genetic Variation
- Genetic Vectors
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed