Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.

The Journal of biological chemistry - 15 Jan 1992

Countaway J L, Nairn A C, Davis R J

Abstract excerpt

The intrinsic protein-tyrosine kinase activity of the epidermal growth factor (EGF) receptor is required for signal transduction. Increased protein-tyrosine kinase activity is observed following the binding of EGF to the receptor. However, signaling is rapidly desensitized during EGF treatment. W...

Topics

Amino Acid Sequence
Animals
Calcium-Calmodulin-Dependent Protein Kinases
Down-Regulation
Endocytosis
Epidermal Growth Factor
ErbB Receptors
Molecular Sequence Data
Mutation
Phosphorylation
Protein Kinases
Protein-Tyrosine Kinases
Rabbits
Rats
Serine
Signal Transduction
Threonine
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 1309762

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1309762-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics