Article
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.
Cell - 26 Jul 1996
Alcedo J, Ayzenzon M, Von Ohlen T, Noll M, Hooper J E
Abstract excerpt
Smoothened (smo) is a segment polarity gene required for correct patterning of every segment in Drosophila. The earliest defect in smo mutant embryos is loss of expression of the Hedgehog-responsive gene wingless between 1 and 2 hr after gastrulation. Since smo mutant embryos cannot respond to ex...
Topics
- Animals
- Base Sequence
- Cell Membrane
- Cloning, Molecular
- Drosophila
- Drosophila Proteins
- Female
- GTP-Binding Proteins
- Gene Expression Regulation, Developmental
- Genes, Insect
- Hedgehog Proteins
- Immunohistochemistry
- In Situ Hybridization
- Male
- Molecular Sequence Data
- Phenotype
- Proteins
- Proto-Oncogene Proteins