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Article

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.

Cell - 26 Jul 1996

Alcedo J, Ayzenzon M, Von Ohlen T, Noll M, Hooper J E

Abstract excerpt

Smoothened (smo) is a segment polarity gene required for correct patterning of every segment in Drosophila. The earliest defect in smo mutant embryos is loss of expression of the Hedgehog-responsive gene wingless between 1 and 2 hr after gastrulation. Since smo mutant embryos cannot respond to exogenous Hedgehog (Hh) but can respond to exogenous Wingless, the smo product functions in Hh signaling. Smo acts...

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Identifiers

PMID: 8706127
DOI: 10.1016/s0092-8674(00)80094-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.PMID 8706127Read ↗

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