Article
Membrane phospholipid control of nucleotide sensitivity of KATP channels.
Science (New York, N.Y.) - 6 Nov 1998
Shyng S L, Nichols C G
Abstract excerpt
Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels couple cell metabolism to electrical activity. Phosphatidylinositol phosphates (PIPs) profoundly antagonized ATP inhibition of KATP channels when applied to inside-out membrane patches. It is proposed that membrane-incorporated PIPs...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Animals
- Binding Sites
- COS Cells
- Cell Line
- Islets of Langerhans
- Mutation
- Myocardium
- Patch-Clamp Techniques
- Phosphatidylinositol 4,5-Diphosphate
- Phosphatidylinositol Phosphates
- Potassium Channels
- Potassium Channels, Inwardly Rectifying
- Receptors, Drug
- Recombinant Fusion Proteins
- Sulfonylurea Receptors