Phosphate stimulates CFTR Cl- channels.

doi:10.1016/S0006-3495(94)80668-X

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Article

Phosphate stimulates CFTR Cl- channels.

Biophysical journal - 1 Nov 1994

Carson M R, Travis S M, Winter M C, Sheppard D N, Welsh M J

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels appear to be regulated by hydrolysis of ATP and are inhibited by a product of hydrolysis, ADP. We assessed the effect of the other product of hydrolysis, inorganic phosphate (P(i)), on CFTR Cl- channel activity using the excised inside-out configuration of the patch-clamp technique. Millimolar concentrations of P(i) caused a dose-dependent...

Topics

3T3 Cells
Adenosine Triphosphate
Animals
Azides
Biophysical Phenomena
Biophysics
Cell Line
Chloride Channels
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

In Vitro Techniques

Membrane Proteins

Mice

Models, Biological

Mutation

Phosphates

Source

Open in PubMed Open full text

Identifiers

PMID: 7532021
DOI: 10.1016/S0006-3495(94)80668-X
PMCID: PMC1225560

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7532021-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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