Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long-chain acyl-CoA esters and phosphatidylinositol phosphates modulate ATP inhibition of KATP channels by the same mechanism.

The Journal of physiology - 15 Oct 2003

Schulze Dirk, Rapedius Markus, Krauter Tobias, Baukrowitz Thomas

Abstract excerpt

Phosphatidylinositol phosphates (PIPs, e.g. PIP2) and long-chain acyl-CoA esters (e.g. oleoyl-CoA) are potent activators of KATP channels that are thought to link KATP channel activity to the cellular metabolism of PIPs and fatty acids. Here we show that the two types of lipid act by the same mechanism: oleoyl-CoA potently reduced the ATP sensitivity of cardiac (Kir6.2/SUR2A) and pancreatic (Kir6.2/SUR1) KATP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyl Coenzyme A
Share to Adenine Nucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channel Blockers

Share to Esters

Share to KATP Channels

Share to Oleic Acid

Share to Phosphatidylinositol Phosphates

Share to RNA, Complementary

Source

Open in PubMed Open full text

Identifiers

PMID: 14561820
DOI: 10.1113/jphysiol.2003.047035
PMCID: PMC2343384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long-chain acyl-CoA esters and phosphatidylinositol phosphates modulate ATP inhibition of KATP channels by the same mechanism.PMID 14561820Read ↗

Activation of adenosine triphosphate-sensitive potassium channels by acyl coenzyme A esters involves multiple phosphatidylinositol 4,5-bisphosphate-interacting residues.Semantic proximity Read ↗

PIP2 and PIP as determinants for ATP inhibition of KATP channels.Semantic proximity Read ↗

Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?Semantic proximity Read ↗

Membrane phospholipid control of nucleotide sensitivity of KATP channels.Semantic proximity Read ↗

Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase.Semantic proximity Read ↗

MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.Semantic proximity Read ↗

Intracellular long-chain acyl CoAs activate TRPV1 channels.Semantic proximity Read ↗

Molecular determinants of KATP channel inhibition by ATP.Semantic proximity Read ↗

Ankyrin regulates KATP channel membrane trafficking and gating in excitable cells.Semantic proximity Read ↗

KATP channels as molecular sensors of cellular metabolism.Semantic proximity Read ↗

Molecular determinants of cardiac K(ATP) channel activation by epoxyeicosatrienoic acids.Semantic proximity Read ↗

Localization of the ATP/phosphatidylinositol 4,5 diphosphate-binding site to a 39-amino acid region of the carboxyl terminus of the ATP-regulated K+ channel Kir1.1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.