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Article

Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating.

1 Jul 1994

Abstract excerpt

Single channel analysis of artificial lipid planar bilayers reconstituted with wild-type human cystic fibrosis transmembrane regulator (CFTR) revealed a 10.3 pS Cl- selective channel that was activated upon phosphorylation with protein kinase A. Gating of this channel was described by a simple kinetic model consisting of a single open burst state and two closed states. The open probability of CFTR channels in...

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Share to Advanced biosensing and bioanalysis techniques
Share to Cystic Fibrosis Research Advances
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Identifiers

PMID: 7518455
DOI: 10.1016/s0021-9258(17)32174-9

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Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating.PMID 7518455Read ↗

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