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Article

Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2).

The Journal of biological chemistry - 9 Mar 2018

Ha Junghoon, Xu Yu, Kawano Takeharu, Hendon Tyler, Baki Lia, Garai Sumanta, Papapetropoulos Andreas, Thakur Ganesh A, Plant Leigh D, Logothetis Diomedes E

Abstract excerpt

Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain, and other peripheral tissues. Phosphatidylinositol 4,5-bisphosphate (PIP2) is a key direct activator of ion channels, including Kir channels. The gasotransmitter carbon monoxide has been shown to regulate Kir channel activity by altering channel-PIP2 interactions. Here, we...

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Identifiers

PMID: 29317494
DOI: 10.1074/jbc.RA117.001679
PMCID: PMC5846148

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