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Article

Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Jun 2007

Kim Donghee, Cavanaugh Eric J

Abstract excerpt

Pungent chemicals such as allyl isothiocyanate (AITC), cinnamaldehyde, and allicin, produce nociceptive sensation by directly activating transient receptor potential A1 (TRPA1) expressed in sensory afferent neurons. In this study, we found that pungent chemicals added to the pipette or bath solut...

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Identifiers

PMID: 17567811
DOI: 10.1523/JNEUROSCI.0623-07.2007
PMCID: PMC6672444

Genes

TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17567811-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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