Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.

Molecular pharmacology - 1 Jun 2000

Gribble F M, Reimann F, Ashfield R, Ashcroft F M

Abstract excerpt

ATP-sensitive K(+) channels are the target for K(+) channel openers such as pinacidil. These channels are formed from pore-forming Kir6. 2 and regulatory sulfonylurea receptor (SUR) subunits. Pinacidil activates channels containing SUR2A (heart, skeletal muscle), but not those containing SUR1 (beta cells). Surprisingly, binding of the pinacidil analog [(3)H]P1075 is dependent on added nucleotides, yet in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate
Share to Antihypertensive Agents
Share to Guanidines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Potassium Channels

Share to Potassium Channels, Inwardly Rectifying

Share to Pyridines

Share to Tritium

Share to Vasodilator Agents

Source

Identifiers

PMID: 10825398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.PMID 10825398Read ↗

Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.Semantic proximity Read ↗

Molecular determinants of KATP channel inhibition by ATP.Semantic proximity Read ↗

Structural basis for the interference between nicorandil and sulfonylurea action.Semantic proximity Read ↗

MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.Semantic proximity Read ↗

Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels.Semantic proximity Read ↗

Potassium channel openers require ATP to bind to and act through sulfonylurea receptors.Semantic proximity Read ↗

Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: implication for dimerization of nucleotide-binding domains to induce channel opening.Semantic proximity Read ↗

Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.Semantic proximity Read ↗

Molecular biology of K(ATP) channels and implications for health and disease.Semantic proximity Read ↗

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.Semantic proximity Read ↗

Substitution of the Walker A lysine by arginine in the nucleotide-binding domains of sulphonylurea receptor SUR2B: effects on ligand binding and channel activity.Semantic proximity Read ↗

Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.