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Article

Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000

Shyng S L, Barbieri A, Gumusboga A, Cukras C, Pike L, Davis J N, Stahl P D, Nichols C G

Abstract excerpt

ATP-sensitive potassium channels (K(ATP) channels) regulate cell excitability in response to metabolic changes. K(ATP) channels are formed as a complex of a sulfonylurea receptor (SURx), a member of the ATP-binding cassette protein family, and an inward rectifier K(+) channel subunit (Kir6.x). Membrane phospholipids, in particular phosphatidylinositol (PI) 4,5-bisphosphate (PIP(2)), activate K(ATP) channels and...

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Identifiers

PMID: 10639183
DOI: 10.1073/pnas.97.2.937
PMCID: PMC15434

Genes

PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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