Article
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 1998
Gribble F M, Tucker S J, Haug T, Ashcroft F M
Abstract excerpt
ATP-sensitive potassium (KATP) channels in the pancreatic beta cell membrane mediate insulin release in response to elevation of plasma glucose levels. They are open at rest but close in response to glucose metabolism, producing a depolarization that stimulates Ca2+ influx and exocytosis. Metabol...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Animals
- Electrophysiology
- Hydrolysis
- Ion Channel Gating
- Islets of Langerhans
- Mice
- Mutation
- Potassium Channels
- Potassium Channels, Inwardly Rectifying
- Receptors, Drug
- Sulfonylurea Receptors
- Xenopus laevis