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Article

Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype.

Clinical pharmacology and therapeutics - 1 Oct 1998

Herrlin K, Massele A Y, Jande M, Alm C, Tybring G, Abdi Y A, Wennerholm A, Johansson I, Dahl M L, Bertilsson L, Gustafsson L L

Abstract excerpt

OBJECTIVE: To investigate the CYP2C19 polymorphism in Tanzanians because this enzyme shows large interindividual differences in activity and metabolizes several drugs of importance in Africa, especially the antimalarial agent chloroguanide (INN, proguanil). METHODS: Two hundred fifty-one Tanzanian healthy volunteers were phenotyped with respect to CYP2C19 with use of a single oral dose of mephenytoin (n = 106), a...

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PMID: 9797796
DOI: 10.1016/S0009-9236(98)90070-4

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