Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype.

doi:10.1016/S0009-9236(98)90070-4

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Article

Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype.

Clinical pharmacology and therapeutics - 1 Oct 1998

Herrlin K, Massele A Y, Jande M, Alm C, Tybring G, Abdi Y A, Wennerholm A, Johansson I, Dahl M L, Bertilsson L, Gustafsson L L

Abstract excerpt

OBJECTIVE: To investigate the CYP2C19 polymorphism in Tanzanians because this enzyme shows large interindividual differences in activity and metabolizes several drugs of importance in Africa, especially the antimalarial agent chloroguanide (INN, proguanil). METHODS: Two hundred fifty-one Tanzania...

Topics

Administration, Oral
Adolescent
Adult
Alleles
Anti-Ulcer Agents
Anticonvulsants
Aryl Hydrocarbon Hydroxylases
Black People
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
DNA Primers
Enzyme Inhibitors
Female
Genotype
Humans

Source

Open in PubMed

Identifiers

PMID: 9797796
DOI: 10.1016/S0009-9236(98)90070-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9797796-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Male

Mephenytoin

Middle Aged