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Article

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study.

Clinical pharmacology and therapeutics - 1 Jun 1995

Balian J D, Sukhova N, Harris J W, Hewett J, Pickle L, Goldstein J A, Woosley R L, Flockhart D A

Abstract excerpt

We compared omeprazole and mephenytoin as probes for the CYP2C19 metabolic polymorphism. Single oral doses of omeprazole (20 mg) or mephenytoin (100 mg) were administered at least 1 week apart to 167 healthy volunteers. Mephenytoin metabolism was measured using the amount of 4'-hydroxymephenytoin and the S/R ratio of mephenytoin in an 8-hour urine collection. Omeprazole hydroxylation was measured using the ratio...

Topics

Adult
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Female
Genotype
Humans
Hydroxylation
Male
Mephenytoin
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mixed Function Oxygenases

Omeprazole

Phenotype

Polymerase Chain Reaction

Reference Values

Source

Identifiers

PMID: 7781266
DOI: 10.1016/0009-9236(95)90229-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7781266-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study.PMID 7781266Read ↗

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