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Article

A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.

Clinical pharmacology and therapeutics - 1 Jan 2006

Sim Sarah C, Risinger Carl, Dahl Marja-Liisa, Aklillu Eleni, Christensen Magnus, Bertilsson Leif, Ingelman-Sundberg Magnus

Abstract excerpt

BACKGROUND AND OBJECTIVE: Many drugs, including proton pump inhibitors and certain antidepressants, are metabolized by the polymorphic cytochrome P450 (CYP) 2C19 enzyme. A significant portion of extensive metabolizers do not reach appropriate drug levels, and our objective was to investigate any genetic background. METHODS: The 5'-flanking region of the CYP2C19 gene from subjects with rapid omeprazole metabolism...

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Identifiers

PMID: 16413245
DOI: 10.1016/j.clpt.2005.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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